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Showing 1–4 of 4 results
Advanced filters: Author: "Taiping Chen" Clear advanced filters

  • En Li and Taiping Chen and colleagues report that lysine specific demethylase 1 (LSD1, also known as AOF2) demethylates and stabilizes DNA methyltransferase 1 (Dnmt1), and that deletion of Aof2 in embryonic stem cells induces progressive loss of DNA methylation.

    • Jing Wang
    • Sarah Hevi
    • Taiping Chen
    Research
    Nature Genetics
    Volume: 41, P: 125-129

  • In mammals, the parental origin-specific expression of imprinted genes is known to be regulated by differential DNA methylation of paternal and maternal alleles, but it is unclear how particular imprinted loci are selected for de novo DNA methylation during gametogenesis. Here it is shown that AOF1, or KDM1B under new nomenclature, functions as a histone H3 lysine 4 demethylase and is required for de novo DNA methylation of some imprinted genes in oocytes.

    • David N. Ciccone
    • Hui Su
    • Taiping Chen
    Research
    Nature
    Volume: 461, P: 415-418

  • This Review describes the diverse roles for histone-modifying and chromatin-remodelling enzymes in mammalian differentiation. These enzymes are involved in both maintaining pluripotency and specifying cell lineage commitment. Recent progress includes their functional characterization in mouse modelsin vivoand a new appreciation of their multifaceted molecular functions.

    • Taiping Chen
    • Sharon Y. R. Dent
    Reviews
    Nature Reviews Genetics
    Volume: 15, P: 93-106