Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–9 of 9 results
Advanced filters: Author: "Tak W. Mak" Clear advanced filters

  • Fundamental differences in the regulation of central metabolic pathways exist between tumours and normal tissue. This Review discusses how the Warburg effect is still applicable to our view of cancer metabolism and new advances in understanding beyond this hypothesis, including regulating anapleurosis and the redox balance.

    • Rob A. Cairns
    • Isaac S. Harris
    • Tak W. Mak
    Reviews
    Nature Reviews Cancer
    Volume: 11, P: 85-95

  • Cytochromec is primarily known for its function in the mitochondria as a key participant in the life-supporting function of ATP synthesis. Yet, cytochrome calso has a prominent role in apoptotic pathways and participates in non-apoptotic processes during development.

    • Yong-Ling P. Ow
    • Douglas R. Green
    • Tak W. Mak
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 9, P: 532-542

  • The p53 family of transcription factors have diverse roles during development and in cancer. However, there is increasing evidence that their ancestral function may have been to regulate unique aspects of maternal fertility.

    • Arnold J. Levine
    • Richard Tomasini
    • Gerry Melino
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 12, P: 259-265

  • Cancer cells have high levels of reactive oxygen species (ROS) owing to metabolic and genetic alterations. The role of ROS in cancer cells is controversial as they can have both pro-tumorigenic and antitumorigenic properties. In this Review, Mak and colleagues discuss recent findings that cancer cells upregulate antioxidant pathways to counteract ROS, and explore the potential of anticancer strategies that target the antioxidant capacity of tumour cells.

    • Chiara Gorrini
    • Isaac S. Harris
    • Tak W. Mak
    Reviews
    Nature Reviews Drug Discovery
    Volume: 12, P: 931-947

  • In this Review, the authors describe how tumour necrosis factor (TNF) signals via its receptors. They explain how TNF is able to promote cell survival or cell death in different contexts and discuss the consequences of deregulated TNF receptor signalling for chronic human diseases. Finally, they discuss new strategies for targeting TNF in the clinic.

    • Dirk Brenner
    • Heiko Blaser
    • Tak W. Mak
    Reviews
    Nature Reviews Immunology
    Volume: 15, P: 362-374