Plasmodiumparasites alter the physiology and morphology of erythrocytes by exporting hundreds of proteins into the host cell. In this Review, de Koning-Wardet al. discuss how these parasites use distinct protein trafficking motifs, protease-mediated polypeptide processing, a novel translocon and membranous structures to induce host cell remodelling and promote their own survival.
- Tania F. de Koning-Ward
- Matthew W.A. Dixon
- Paul R. Gilson