Nuclear hormone receptors are transcription factors that regulate multiple biological pathways and may provide protection against metabolic, inflammatory and cardiovascular diseases. In this Review, Wang and colleagues discuss the evidence that supports a role for nuclear hormone receptors in the pathogenesis of diabetic nephropathy and describe how the manipulation of these receptors may provide new avenues for the treatment of this disease.
- Xiaoxin X. Wang
- Tao Jiang
- Moshe Levi
