The authors report a previously unappreciated miR-26a-mediated regulatory model in which miR-26a promotes invasion/metastasis by inhibiting the phosphatase PTEN and inhibits cell proliferation by repressing the methyltransferase EZH2 in hepatocellular carcinoma. Although therapeutic miR-26a delivery significantly suppresses tumorigenesis in mice, further studies are warranted before it is a relevant as a target for HCC therapy.
- Wen-Tao Zhao
- Xiao-Lin Lin
- Dong Xiao
