Alterations in neural-stem-cell (NSC) homeostasis can contribute to the consequences of neurodegenerative diseases, healthy ageing and tissue repair after damage. This Review discusses emerging information on the function of insulin-like growth factors (IGFs) and IGF and/or insulin receptor signalling in the context of NSC regulation. The authors also propose a model for IGF-II in which the choroid plexus is a major component of the NSC niche.
- Amber N. Ziegler
- Steven W. Levison
- Teresa L. Wood
