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Showing 1–3 of 3 results
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  • Genome-wide association meta-analyses of waist-to-hip ratio adjusted for body mass index in more than 224,000 individuals identify 49 loci, 33 of which are new and many showing significant sexual dimorphism with a stronger effect in women; pathway analyses implicate adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution.

    • Dmitry Shungin
    • Thomas W. Winkler
    • Karen L Mohlke
    Research
    Nature
    Volume: 518, P: 187-196

  • A genome-wide association study and Metabochip meta-analysis of body mass index (BMI) detects 97 BMI-associated loci, of which 56 were novel, and many loci have effects on other metabolic phenotypes; pathway analyses implicate the central nervous system in obesity susceptibility and new pathways such as those related to synaptic function, energy metabolism, lipid biology and adipogenesis.

    • Adam E. Locke
    • Bratati Kahali
    • Elizabeth K. Speliotes
    Research
    Nature
    Volume: 518, P: 197-206

  • Yukinori Okada and colleagues report a meta-analysis of genome-wide association studies for kidney function–related traits in 71,149 individuals from east Asia. They identify 17 loci newly associated with the concentrations of blood urea nitrogen, serum creatinine and uric acid, and with glomerular filtration rate (eGFRcrea), several of which are also associated with chronic kidney disease.

    • Yukinori Okada
    • Xueling Sim
    • Toshihiro Tanaka
    Research
    Nature Genetics
    Volume: 44, P: 904-909