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Showing 1–16 of 16 results
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  • Peptide synthesis can take place directly on RNA, which suggests how a nucleic acid–protein world might have originated on early Earth.

    • Felix Müller
    • Luis Escobar
    • Thomas Carell
    ResearchOpen Access
    Nature
    Volume: 605, P: 279-284

  • Adding one further base pair to the classic Watson–Crick scheme not only expands the genetic code but also offers opportunities to modify the structure and function of DNA. It has now been shown that an artificial metal–salen base pair can be enzymatically incorporated into DNA duplexes and even amplified by PCR.

    • Corinna Kaul
    • Markus Müller
    • Thomas Carell
    Research
    Nature Chemistry
    Volume: 3, P: 794-800

  • Mannosyl-queuosine (manQ) is a non-canonical RNA nucleoside present in the anticodon loop of certain tRNAs. Here, the authors use a combination of total synthesis and mass spectrometry to contradict the literature-reported structure and show that manQ features an alpha-allyl connectivity of its mannose moiety.

    • Markus Hillmeier
    • Mirko Wagner
    • Thomas Carell
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9

  • The combination of heavy isotope labeling and ultra-high-pressure liquid chromatography coupled to triple-quadrupole mass spectrometry (UHPLC–MS) is used to quantify modified genomic cytosines in pluripotent stem cells in different states and reveals active turnover of methylcytidine in oxidation-dependent and oxidation-independent manners.

    • Fabio Spada
    • Sarah Schiffers
    • Thomas Carell
    Research
    Nature Chemical Biology
    Volume: 16, P: 1411-1419

  • α-ketoglutarate (αKG) is an intermediate in the tricarboxylic acid cycle that is required in the nucleus for genomic DNA demethylation by Tet3. Here, the authors show that the enzyme glutamate dehydrogenase, which converts glutamate to αKG, is redirected from the mitochondria to the nucleus.

    • Franziska R. Traube
    • Dilara Özdemir
    • Thomas Carell
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • Computers use transistor-based logic gates as the basis of their functions, but molecular logic gates would make them much faster. A report of DNA-based logic gates could be a first step towards molecular computing.

    • Thomas Carell
    News & Views
    Nature
    Volume: 469, P: 45-46

  • How RNA building blocks have formed on an early Earth by a continuous process is still a mystery awaiting its solution. Here, the authors report that fluctuations of physical parameters like temperature and pH could have been enough to facilitate nucleoside formation from simple starting materials.

    • Sidney Becker
    • Christina Schneider
    • Thomas Carell
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-9

  • Direct conversion of 5-fdC into dC by C–C bond breakage is revealed by metabolic tracing studies through incorporation of synthetic stable isotope- and (R)-2′-fluorine-labeled dC and fdC derivatives into the genome of cultured mammalian cells.

    • Katharina Iwan
    • René Rahimoff
    • Thomas Carell
    Research
    Nature Chemical Biology
    Volume: 14, P: 72-78

  • 5-hydroxymethyluracil (hmU) is an oxidative DNA lesion and a potential intermediate in DNA repair–coupled DNA demethylation pathways. Isotopic labeling and MS reveal that hmU is produced directly by Tet-mediated oxidation of thymine in mouse embryonic stem cells, suggesting a functional role for hmU in stem cells.

    • Toni Pfaffeneder
    • Fabio Spada
    • Thomas Carell
    Research
    Nature Chemical Biology
    Volume: 10, P: 574-581

  • Certain oxidative DNA lesions adopt altered conformational preferences that lead to mutations during replication. Biochemical and structural data reveal that for formamidopyrimidine lesions, tautomerization and altered base pair geometry in the DNA polymerase active site, rather than changes in glycosidic torsion angle, direct the mutagenicity of these lesions.

    • Tim H Gehrke
    • Ulrike Lischke
    • Thomas Carell
    Research
    Nature Chemical Biology
    Volume: 9, P: 455-461

  • A comprehensive proteomics screen for ‘reader’ proteins that recognize m6A-modified RNA reveals that the modification both promotes and prevents the binding of factors that control mRNA homeostasis in mammalian cells.

    • Raghu R Edupuganti
    • Simon Geiger
    • Michiel Vermeulen
    Research
    Nature Structural & Molecular Biology
    Volume: 24, P: 870-878