Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–3 of 3 results
Advanced filters: Author: "Thomas Duchaine" Clear advanced filters

  • The type III ribonuclease DCR-1 is essential for ERI endogenous RNAi and exogenous RNAi in Caenorhabditis elegans. A new study shows that DCR-1 forms exclusive complexes in each pathway, and characterization of the ERI complex implicates a tudor domain protein in tethering an RNA-dependent RNA polymerase to DCR-1 to potentiate endo-RNAi.

    • Caroline Thivierge
    • Neetha Makil
    • Thomas F Duchaine
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 90-97

    • Ahilya N Sawh
    • Thomas F Duchaine
    News & Views
    Nature Structural & Molecular Biology
    Volume: 19, P: 365-366

  • Germline mutations inDICER1 can lead to DICER1 syndrome, which is characterized by the predisposition of various types of cancer in childhood and during early adulthood. Additionally, specific DICER1 mutations occur in tumours. This Review discusses germline and somatically-acquired DICER1mutations and their effects on tumorigenesis.

    • William D. Foulkes
    • John R. Priest
    • Thomas F. Duchaine
    Reviews
    Nature Reviews Cancer
    Volume: 14, P: 662-672