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Showing 1–4 of 4 results
Advanced filters: Author: "Thomas Gasser" Clear advanced filters

  • Andrew Singleton, Thomas Gasser and colleagues report results of a genome-wide association study of Parkinson's disease among individuals of European ancestry. They find genome-wide significant associations at two loci, SNCA and MAPT, and provide supporting evidence for a new risk locus on 1q32.

    • Javier Simón-Sánchez
    • Claudia Schulte
    • Thomas Gasser
    Research
    Nature Genetics
    Volume: 41, P: 1308-1312

  • Mutations in the gene, GBA1, cause Gaucher’s disease, and are a strong risk factor for the development of Parkinson’s disease. Here the authors use cells derived from Parkinson’s patients with GBA1mutations to model the disease, and reveal changes in cellular recycling systems that may promote neurodegeneration.

    • David C. Schöndorf
    • Massimo Aureli
    • Michela Deleidi
    Research
    Nature Communications
    Volume: 5, P: 1-17

  • Neuroprotective and/or disease-modifying treatments are urgently needed for Parkinson's disease. This Review describes how an increased understanding of genetic mutations that lead to Parkinson's disease, better translation between preclinical animal models and clinical research, and improved design of future clinical trials are priorities for overcoming the limitations of current therapies.

    • Wassilios G. Meissner
    • Mark Frasier
    • Erwan Bezard
    Reviews
    Nature Reviews Drug Discovery
    Volume: 10, P: 377-393