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Showing 1–5 of 5 results
Advanced filters: Author: "Thomas Langer" Clear advanced filters

  • The health of the proteome in the face of multiple and diverse challenges directly influences the health of the cell and the lifespan of the organism. A recent meeting held in Nara, Japan, provided an exciting platform for scientific exchange and provocative discussions on the biology of proteins and protein homeostasis across multiple scales of analysis and model systems.

    • Richard I Morimoto
    • Arnold J M Driessen
    • Thomas Langer
    News & Views
    Nature Structural & Molecular Biology
    Volume: 18, P: 1-4

  • Saita et al. show that PARL cleaves Smac (also known as DIABLO) to generate an IAP-binding motif required for its apoptotic activity, identifying PARL-mediated Smac processing as a pro-apoptotic mitochondrial pathway.

    • Shotaro Saita
    • Hendrik Nolte
    • Thomas Langer
    Research
    Nature Cell Biology
    Volume: 19, P: 318-328

  • Mitochondrial proteases can be classified into subgroups depending on their function and location. They are highly specific and modulate biochemical activities that are essential for mitochondrial function and integrity. Impaired or dysregulated function of mitoproteases is associated with ageing and longevity, as well as with pathological conditions and human hereditary diseases.

    • Pedro M. Quirós
    • Thomas Langer
    • Carlos López-Otín
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 16, P: 345-359

  • Recent findings revealed the extent to which mitochondrial translation and other cellular processes are mutually controlled. Mitochondrial translation is coordinated with the assembly of respiratory chain complexes and is positively regulated by microRNAs imported from the cytoplasm. In turn, mitochondrial translation stress activates retrograde signalling pathways that suppress cell proliferation.

    • Ricarda Richter-Dennerlein
    • Sven Dennerlein
    • Peter Rehling
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 16, P: 586-592