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Showing 1–16 of 16 results
Advanced filters: Author: "Thomas Misgeld" Clear advanced filters

  • In this study, Tai et al. provide insights into the metabolic and bioenergetic responses in the axonal compartment in the context of multiple sclerosis. Moreover, they show how upregulating the tricarboxylic acid cycle confers protection against neuroinflammation-induced energy deprivation.

    • Yi-Heng Tai
    • Daniel Engels
    • Thomas Misgeld
    ResearchOpen Access
    Nature Metabolism
    Volume: 5, P: 1364-1381

  • Synapse loss is prominent in the cortex in multiple sclerosis (MS). In a cortical MS model, Jafari et al. show that phagocytes remove synapses by engulfment, which is triggered by local calcium accumulations and prevented by blocking colony-stimulating factor 1 signaling.

    • Mehrnoosh Jafari
    • Adrian-Minh Schumacher
    • Martin Kerschensteiner
    Research
    Nature Neuroscience
    Volume: 24, P: 355-367

  • Oligodendrocyte damage is a key component of demyelinating diseases. Here, the authors use in vivolight and correlated electron microscopy in EAE mouse models, and find early damage occurs at the myelin sheath before spreading to the oligodendrocyte cell body.

    • Elisa Romanelli
    • Doron Merkler
    • Martin Kerschensteiner
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-10

  • Neural connectivity in brain tissue is imaged by labeling the extracellular space.

    • Shahrzad Askari
    • Thomas Misgeld
    News & Views
    Nature Biotechnology
    P: 1-2

  • A potential therapeutic strategy for spinal cord injury (SCI) is to maintain continuity of damaged axons after contusion, but the viability of such strategies depends on the degree to which initially injured axons can recover. Here the authors use morphological and molecular in vivoimaging after contusion SCI in mice, to show that injured axons persist in a metastable state for hours.

    • Philip R. Williams
    • Bogdan-Nicolae Marincu
    • Thomas Misgeld
    Research
    Nature Communications
    Volume: 5, P: 1-11

  • Fiducial marks that can be visualized by both light and electron microscopy are generated by 'branding' fixed tissue with a near-infrared laser and will facilitate correlative light and electron microscopy.

    • Derron Bishop
    • Ivana Nikić
    • Thomas Misgeld
    Research
    Nature Methods
    Volume: 8, P: 568-570

  • Improved expansion microscopy provides a super-resolution method that is accessible to any laboratory with a fluorescence microscope.

    • Peter Engerer
    • Caroline Fecher
    • Thomas Misgeld
    News & Views
    Nature Biotechnology
    Volume: 34, P: 928-930

  • Microtubule dynamics in neurons play critical roles in physiology, injury and disease. Here the authors develop a transgenic mouse line expressing a fluorescently tagged version of the microtubule binding protein EB3, and using a range of imaging techniques, study microtubule dynamics under normal and injury conditions in living mice.

    • Tatjana Kleele
    • Petar Marinković
    • Thomas Misgeld
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-10

  • Axonal degeneration is a hallmark of multiple sclerosis, but it remains unclear what triggers degeneration. By monitoring the development of axonal damage in a mouse model of multiple sclerosis, Ivana Nikić et al. describe a new variant of axonal degeneration. Axonal damage is present in myelinated axons and is reversible using scavengers of reactive oxygen and nitrogen species, thereby suggesting that early stages of degeneration may be amenable to therapeutic intervention.

    • Ivana Nikić
    • Doron Merkler
    • Martin Kerschensteiner
    Research
    Nature Medicine
    Volume: 17, P: 495-499

  • Michael Breckwoldt and colleagues have developed a new approach to follow the mitochondrial redox potential of neurons with high spatio-temporal resolution. This multiparametric in vivo imaging approach is based on the transgenic expression of a biosensor for glutathione redox potential in neuronal mitochondria, with utility demonstrated in mouse models of amyotrophic lateral sclerosis and spinal cord injury. It should prove useful for studying mitochondrial pathology in neurological disease models.

    • Michael O Breckwoldt
    • Franz M J Pfister
    • Thomas Misgeld
    Research
    Nature Medicine
    Volume: 20, P: 555-560

  • Misgeld and Kerschensteiner review howin vivooptical imaging techniques can be used to study the aetiology and therapeutics of neurological disorders. They discuss the challenges of integrating real-time observations with the molecular mechanisms and clinical manifestation of neurological diseases.

    • Thomas Misgeld
    • Martin Kerschensteiner
    Reviews
    Nature Reviews Neuroscience
    Volume: 7, P: 449-463