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Showing 1–2 of 2 results
Advanced filters: Author: "Thomas Pietschmann" Clear advanced filters

  • There is a need for effective antiviral drugs against RSV infection. Conducting an RSV repurposing screen using the ReFRAME library Sake et al. identify lonafarnib as an RSV fusion protein inhibitor, characterize its binding site within the viral protein and show its antiviral effects in a mouse model.

    • Svenja M. Sake
    • Xiaoyu Zhang
    • Thomas Pietschmann
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • To propagate, the hepatitis C virus relies on entry into liver cells. Ironically, cellular proteins that normally assemble firm seals between adjacent cells serve as crucial keys by which the virus gains access.

    • Thomas Pietschmann
    News & Views
    Nature
    Volume: 457, P: 797-798