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Showing 1–3 of 3 results
Advanced filters: Author: "Thomas Scherer" Clear advanced filters

  • Obesity is associated with leptin resistance and rising blood leptin levels while central leptin exposure may be limited. Here, the authors show that brain leptin infusion reduces hepatic lipid content in rats by increasing hepatic VLDL secretion and lowering liver de novo lipogenesis via a vagal mechanism.

    • Martina Theresa Hackl
    • Clemens Fürnsinn
    • Thomas Scherer
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • A new study used several mouse mutants to study insulin receptor function specifically in the ventromedial nucleus of the hypothalamus (VMH), and found a role for VMH insulin signaling in promoting high-fat diet–induced obesity.

    • Chun-Xia Yi
    • Thomas Scherer
    • Matthias H Tschöp
    News & Views
    Nature Neuroscience
    Volume: 14, P: 806-808

  • This Review critically evaluates the studies that support and refute the role of brain insulin in systemic nutrient partitioning. The authors discuss the role of brain insulin in metabolic control and the contribution of brain insulin resistance to metabolic disease and assess the therapeutic potential of enhancing or restoring brain insulin signalling in metabolic disease.

    • Thomas Scherer
    • Kenichi Sakamoto
    • Christoph Buettner
    Reviews
    Nature Reviews Endocrinology
    Volume: 17, P: 468-483