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Showing 1–4 of 4 results
Advanced filters: Author: "Thomas Tuschl" Clear advanced filters
  • Analyses of post-transcriptional gene regulation and the protein factors involved have been substantially driven forward by technological advances such as next-generation sequencing and modern protein mass spectrometry. This Analysis provides a census of 1,542 manually curated RNA-binding proteins, for which the authors have investigated interactions with different classes of RNA, evolutionary conservation, abundance and tissue-specific expression.

    • Stefanie Gerstberger
    • Markus Hafner
    • Thomas Tuschl
    Research
    Nature Reviews Genetics
    Volume: 15, P: 829-845
  • The microRNA-induced silencing complex (miRISC) protein TNRC6 (also called GW182) uses dispersed tryptophan-containing repeats in unstructured regions to recruit the CCR4–NOT nuclease complex leading to mRNA deadenylation and inhibition of translation initiation according to new research.

    • Markus Hafner
    • Manuel Ascano Jr
    • Thomas Tuschl
    News & Views
    Nature Structural & Molecular Biology
    Volume: 18, P: 1181-1182
  • Genetic studies have revealed a large number of gene mutations that can lead to the development of cystic kidney disease, but interpretation of genetic findings is complex and requires knowledge of differential diagnoses. This Review describes a clinical approach to the diagnosis of cystic kidney diseases on the basis of both kidney phenotype and extrarenal manifestations of the underlying disorder, in combination with genetic testing in selected patients.

    • Christine E. Kurschat
    • Roman-Ulrich Müller
    • Thomas Benzing
    Reviews
    Nature Reviews Nephrology
    Volume: 10, P: 687-699