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Showing 1–2 of 2 results
Advanced filters: Author: "Tingting Yang" Clear advanced filters

  • Human Bestrophin1 (hBest1), a calcium-activated chloride channel in retinal pigment epithelium (RPE), is essential for retina physiology. Using electrophysiological and structural approaches, the authors uncover an ATP-dependent activation mechanism of hBest1, and identify an ATP-binding motif.

    • Yu Zhang
    • Alec Kittredge
    • Tingting Yang
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • Ji and Kittredge et al. demonstrate that the neck and aperture of human Bestrophin1, a Ca2+-activated Cl- channel, are both Ca2+-dependent gates. By showing hyper-activity of Bestrophin1, which is associated with its enhanced gate opening in the presence of three patient-derived mutations, this study provides mechanistic insights into the gain-of-function mutations that cause macular degenerative disease.

    • Changyi Ji
    • Alec Kittredge
    • Tingting Yang
    ResearchOpen Access
    Communications Biology
    Volume: 2, P: 1-13