Key roles in cancer development have been established for PI3K and PTEN — enzymes that regulate the levels of phosphatidylinositol-3,4,5-trisphosphate, but several other phosphoinositide-modifying enzymes have been implicated in the generation and progression of tumours. New insights into the mechanisms and the extent of their involvement in cancer are summarized in this Review.
- Tom D. Bunney
- Matilda Katan
