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Showing 1–11 of 11 results
Advanced filters: Author: "Tom Misteli" Clear advanced filters

  • DNA repair occurs in the context of nuclear architecture. Assembly of the repair machinery on damaged chromatin and the ensuing signalling events require tight spatial and temporal coordination. Higher-order chromatin structure, chromatin dynamics and non-random global genome organization also influence genome maintenance.

    • Tom Misteli
    • Evi Soutoglou
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 10, P: 243-254

  • A single-cell analysis suggests that the 3D location of chromosomes in the cell nucleus contributes to their likelihood of being involved in genomic rearrangements associated with cancer.

    • Krishnendu Guin
    • Tom Misteli
    News & Views
    Nature
    Volume: 607, P: 454-455

  • The structure of chromatin is associated with its function, but precisely how is unclear. New data show that the higher-order architecture of the genome is similar among cell types with widely variant fates and gene expression patterns, thus challenging the view that chromatin domains determine function in the genome.

    • Tom Misteli
    • Elizabeth H. Finn
    News & Views
    Nature Genetics
    Volume: 53, P: 426-427

  • How cells build their internal structures remains one of the central mysteries in cell biology. If the cell nucleus is anything to go by, stochastic assembly and self-organization seem to be key.

    • Tom Misteli
    News & Views
    Nature
    Volume: 456, P: 333-334

  • A new computational approach gives us the best chance at understanding how genomes are arranged in three-dimensional space and what that may mean for their function.

    • Tom Misteli
    News & Views
    Nature Biotechnology
    Volume: 30, P: 55-56

  • What makes a stem cell is still poorly understood. Recent studies have uncovered that chromatin might hold some of the keys to how embryonic stem cells maintain their pluripotency, their ability to self-renew and induce lineage specification.

    • Eran Meshorer
    • Tom Misteli
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 7, P: 540-546

  • Repair of a chromosome break can result in part of a chromosome attaching to a different chromosome, causing gene deregulation and disease. Roukos and Misteli discuss the spatial aspect of chromosome translocation and the role of DNA repair pathways in this process.

    • Vassilis Roukos
    • Tom Misteli
    Reviews
    Nature Cell Biology
    Volume: 16, P: 293-300

  • The majority of common diseases are associated with ageing. Diseases that cause premature ageing serve as natural model systems for studying the mechanisms of ageing and disease, as they share similar cellular and molecular hallmarks, including genomic instability, metabolic defects and loss of regenerative capacity.

    • Nard Kubben
    • Tom Misteli
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 18, P: 595-609

  • Insights into eukaryotic, bacterial and archaeal RNA-based regulatory systems, including microRNAs, small interfering RNAs, clustered regularly interspaced short palindromic repeats (CRISPR) RNA and small RNAs that are dependent on the RNA chaperone protein Hfq, have revealed that they achieve specificity using similar strategies. Specifically, the presentation of short 'seed sequences' within a ribonucleoprotein complex facilitates the search for and recognition of targets.

    • Stanislaw A. Gorski
    • Jörg Vogel
    • Jennifer A. Doudna
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 18, P: 215-228