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Showing 1–7 of 7 results
Advanced filters: Author: "Tony Pawson" Clear advanced filters

  • The past few years have marked significant anniversaries in the field of signal transduction. Here, six researchers reflect on the context in which these discoveries were made, and how our concept of cell signalling has evolved during the past three decades.

    • Nancy E. Hynes
    • Philip W. Ingham
    • Tony Pawson
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 14, P: 393-398

  • The ability of methylarginine sites to serve as binding motifs for Tudor proteins, and the functional significance of this, is now becoming clear. Tudor proteins are thought to interact with methylated PIWI proteins and regulate the PIWI-interacting RNA pathway in the germ line.

    • Chen Chen
    • Timothy J. Nott
    • Tony Pawson
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 12, P: 629-642

  • New work shows that activation of the Ras guanine nucleotide exchange factor SOS is dependent upon the membrane density of phosphatidylinositol-4,5-bisphosphate (PIP2) and GTP-bound Ras. These signals synergize to release the autoinhibitory DH-PH domain, while the histone domain fine-tunes SOS activation in response to PIP2.

    • Greg M Findlay
    • Tony Pawson
    News & Views
    Nature Structural & Molecular Biology
    Volume: 15, P: 538-540

  • Proteins are controlled by post-translational modifications that can be recognized by specific protein-interaction domains. These domains read the state of the proteome and therefore couple post-translational modifications to cellular organization. But how domodification-dependent interactionssynergize to regulate cell behaviour?

    • Bruce T. Seet
    • Ivan Dikic
    • Tony Pawson
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 7, P: 473-483

  • This article proposes a new model outlining the early steps in the development of serous ovarian cancer. This model suggests that homologous recombination repair deficiency initiates a cascade of molecular events that sculpt the evolution of high-grade serous ovarian cancer and dictate its response to therapy.

    • David D. L. Bowtell
    Reviews
    Nature Reviews Cancer
    Volume: 10, P: 803-808

  • Lys and Arg methylation on non-histone proteins regulates various signalling pathways, and its crosstalk with other post-translational modifications and with histone methylation affects cellular processes such as transcription and DNA damage repair. Advances in proteomics now allow us to decode the methylproteome and elucidate its functions.

    • Kyle K. Biggar
    • Shawn S.-C. Li
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 16, P: 5-17