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Showing 1–3 of 3 results
Advanced filters: Author: "Trevor A. Graham" Clear advanced filters

  • DNA damage can cause mutations due to failure of DNA repair and errors during DNA replication. Tracking the strand of the DNA double helix on which damage occurs has shed light on processes that affect tumour evolution.

    • Trevor A. Graham
    • Sarah E. McClelland
    News & Views
    Nature
    Volume: 583, P: 207-209

  • New research backs the contentious idea that solid tumours are not masses of equivalent cells, but instead contain cancer stem cells that support tumour maintenance. Here, two experts provide complementary views on the findings and on the implications for potential therapies. See Letters p.522 & p.527

    • Richard J. Gilbertson
    • Trevor A. Graham
    News & Views
    Nature
    Volume: 488, P: 462-463

  • Field cancerization underlies the development of many types of cancer. This Review examines the biological mechanisms that drive the evolution of cancerized fields and discusses how measuring field evolution could improve cancer risk prediction in patients with pre-malignant disease.

    • Kit Curtius
    • Nicholas A. Wright
    • Trevor A. Graham
    Reviews
    Nature Reviews Cancer
    Volume: 18, P: 19-32