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Showing 1–7 of 7 results
Advanced filters: Author: "Trevor Graham" Clear advanced filters

  • Common driver mutations in colorectal cancer (CRC) are not always consistent with frequent mutational signatures. Here, the authors analyse spatially annotated colon crypts in CRC patients and find mutational signatures of pks+ E. coli that are consistent with driver mutations, suggesting a potential role of pks+ E. coli in carcinogenesis.

    • Bingjie Chen
    • Daniele Ramazzotti
    • Andrea Sottoriva
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-9

  • A study maps genetic and epigenetic heterogeneity of primary colorectal adenomas and cancers at single-clone resolution through spatial multi-omic profiling of individual glands and adjacent normal tissue.

    • Timon Heide
    • Jacob Househam
    • Andrea Sottoriva
    ResearchOpen Access
    Nature
    Volume: 611, P: 733-743

  • Intratumour genetic ancestry only infrequently affects gene expression traits and subclonal evolution in colorectal cancer, with most genetic intratumour variation having no detected phenotypic consequence and transcriptional plasticity being widespread within a tumour.

    • Jacob Househam
    • Timon Heide
    • Trevor A. Graham
    ResearchOpen Access
    Nature
    Volume: 611, P: 744-753

  • Many archived tumour samples are stored as formalin-fixed and paraffin-embedded (FFPE) blocks, but this treatment can impact downstream genomics analyses. Here, the authors derive the mutational signatures of formalin on the cancer genome, and present FFPEsig, an algorithm that can distinguish and correct FFPE mutational signatures in archived cancer samples.

    • Qingli Guo
    • Eszter Lakatos
    • Ville Mustonen
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • Based on a consensus conference of experts in the evolution and ecology of cancer, this article proposes a framework for classifying tumours that includes four evolutionary and ecological processes: neoplastic cell diversity and changes over time in that diversity, hazards to cell survival and available resources.

    • Carlo C. Maley
    • Athena Aktipis
    • Darryl Shibata
    ReviewsOpen Access
    Nature Reviews Cancer
    Volume: 17, P: 605-619

  • Clonal evolution begins before the development of neoplasia in IBD, accelerated by repeated cycles of epithelial wounding and repair. Here, the authors summarize the biological drivers of mutant clone selection in IBD and discuss how an evolutionary perspective can improve cancer surveillance programmes and dysplasia management.

    • Chang-Ho R. Choi
    • Ibrahim Al Bakir
    • Trevor A. Graham
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 14, P: 218-229