The authors provide a brief overview of the physiological and pharmacological relevance of proteins that translocate organic anions. Focusing on OATs located in the basolateral membrane of proximal tubule cells, the authors discuss data fromXenopusoocytes and knockout mice. The potential for new findings to shed light on an individual patient's response to treatment with a particular drug, and the risks of toxic effects, are emphasized.
- Sanjay K Nigam
- Kevin T Bush
- Vibha Bhatnagar
