Pancreatic cancer has a poor prognosis and it is often diagnosed at an advanced stage, which makes it difficult to treat. Various natural and synthetic compounds have shown efficacy as chemopreventive agents in cellular andin vivoanimal models of pancreatic cancer. Few clinical trials of pancreatic cancer chemopreventive agents have been completed and some are in early stages. This Review discusses the current state of the field of pancreatic cancer chemo-prevention and highlights the challenges ahead.
- Silvia D. Stan
- Shivendra V. Singh
- Randall E. Brand