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Showing 1–2 of 2 results
Advanced filters: Author: "Victor L J Tybulewicz" Clear advanced filters

  • This article describes the promising technologies for generating humanized mouse models — that is, mouse strains containing large sections of human coding and non-coding sequences — for the purposes of improving our understanding of basic genome function and disease and discovering effective therapies.

    • Anny Devoy
    • Rosie K. A. Bunton-Stasyshyn
    • Elizabeth M. C. Fisher
    Reviews
    Nature Reviews Genetics
    Volume: 13, P: 14-20

  • Individuals with Down syndrome have an enhanced risk of developing early onset Alzheimer disease. Here, the authors describe the features of Alzheimer disease in Down syndrome and show how understanding the genetic and pathogenic mechanisms of this form of Alzheimer disease may shed light on more general mechanisms of neurodegeneration.

    • Frances K. Wiseman
    • Tamara Al-Janabi
    • André Strydom
    Reviews
    Nature Reviews Neuroscience
    Volume: 16, P: 564-574