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Showing 1–6 of 6 results
Advanced filters: Author: "Victor Nizet" Clear advanced filters
  • A relatively obscure immune cell, the eosinophil, has a dramatic way of defending against pathogens. It rapidly ejects mitochondrial DNA, ensnaring bacteria and hastening their demise (pages 949–953).

    • Victor Nizet
    • Marc E Rothenberg
    News & Views
    Nature Medicine
    Volume: 14, P: 910-912
  • During infection, the inflammatory immune response can cause pain by activating nociceptor neurons. A bacterial pathogen also seems to stimulatepain directly, modulating the immune response in its favour. See Article p.52

    • Victor Nizet
    • Tony Yaksh
    News & Views
    Nature
    Volume: 501, P: 43-44
  • At low levels of oxygen at sites of tissue infection, innate immune cells can adapt to survive and even enhance their antimicrobial functions. Recent studies show how this is controlled by hypoxia-inducible factor (HIF) downstream of nuclear factor-κB activation.

    • Victor Nizet
    • Randall S. Johnson
    Reviews
    Nature Reviews Immunology
    Volume: 9, P: 609-617
  • Pathogens block or subvert host cellular processes to promote successful infection. One host protein that is targeted by invading pathogens is the small GTPase RAB11, which functions in vesicular trafficking. Bier and colleagues discuss the various mechanisms that pathogens have evolved to disrupt or subvert RAB11-dependent pathways as part of their infection strategy.

    • Annabel Guichard
    • Victor Nizet
    • Ethan Bier
    Reviews
    Nature Reviews Microbiology
    Volume: 12, P: 624-634
  • Group AStreptococcuscan cause devastating infections with high mortality rates. Here, Walker and colleagues describe the bacterial virulence factors that allow this species to infect tissues and escape destruction in neutrophils, and discuss how genetic changes in a two-component regulatory system promote pathogenicity.

    • Jason N. Cole
    • Timothy C. Barnett
    • Mark J. Walker
    Reviews
    Nature Reviews Microbiology
    Volume: 9, P: 724-736
  • In this Review, Miller and colleagues discuss the arsenal of effector proteins that salmonellae use to manipulate their animal hosts, in addition to the host response to these infections. The authors also discuss the challenges ahead for unravelling the mechanistic details of effector function.

    • Doris L. LaRock
    • Anu Chaudhary
    • Samuel I. Miller
    Reviews
    Nature Reviews Microbiology
    Volume: 13, P: 191-205