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Showing 1–9 of 9 results
Advanced filters: Author: "Vincenzo Costanzo" Clear advanced filters

  • Double-strand breaks in DNA activate the kinases ATM and ATR, which block entry into mitosis. ATM and ATR also delay mitotic progression by controlling spindle assembly in Xenopus egg extracts through the phosphorylation of the centrosomal protein CEP63, leading to its delocalization from the centrosome.

    • Eloise Smith
    • Donniphat Dejsuphong
    • Vincenzo Costanzo
    Research
    Nature Cell Biology
    Volume: 11, P: 278-285

  • During embryonic development, it is vital to maintain rapid genome duplication. Here, the authors shed light on the mechanism by revealing that SSRP1 stimulates replication origin assembly on somatic nuclei in Xenopus laevis egg extract by promoting histone H1 eviction from somatic chromatin.

    • Lucia Falbo
    • Erica Raspelli
    • Vincenzo Costanzo
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • CEP63 is a centrosomal protein that is mutated in the microcephaly disease Seckel syndrome. Here the authors disrupt Cep63 in the mouse and find that neural progenitor cells undergo p53-dependent cell death, and uncover a role for CEP63 in ensuring correct meiotic recombination in male gametes.

    • Marko Marjanović
    • Carlos Sánchez-Huertas
    • Travis H. Stracker
    Research
    Nature Communications
    Volume: 6, P: 1-14

  • A system to reconstitute a collapsed replication fork using Xenopus laevis egg extracts is developed. The study shows that upon fork collapse, DNA Pol epsilon and the GINS complex are uncoupled from the replisome, and their reloading onto DNA requires repair proteins Rad51 and Mre11.

    • Yoshitami Hashimoto
    • Fabio Puddu
    • Vincenzo Costanzo
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 17-24

  • The cell cycle division protein Cdc45 is required for genome duplication in eukaryotes. Here, the authors determine the crystal structure of human Cdc45 and combine it with functional data to improve our understanding of its role in DNA replication.

    • Aline C. Simon
    • Vincenzo Sannino
    • Luca Pellegrini
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-15

  • GEMC1 is a newly discovered protein required for initiation of DNA replication in Xenopus. xGEMC1 interacts with the replication factors TopBP1 and Cdk2 and promotes TopBP1- and Cdk2-dependent loading of Cdc45 onto replication origins.

    • Alessia Balestrini
    • Claudia Cosentino
    • Vincenzo Costanzo
    Research
    Nature Cell Biology
    Volume: 12, P: 484-491

  • Recent studies have provided insights into the sources of endogenous replication stress, which can result in DNA damage, checkpoint activation and genome-wide replication fork slowing. The authors review established mechanisms involved in the replication stress response, and propose a new model that reconciles data gained from different cellular models.

    • Hervé Técher
    • Stéphane Koundrioukoff
    • Michelle Debatisse
    Reviews
    Nature Reviews Genetics
    Volume: 18, P: 535-550