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Showing 1–3 of 3 results
Advanced filters: Author: "Warren J. Leonard" Clear advanced filters

  • In this Review, the authors discuss the central roles of the common cytokine receptor γ-chain (γc) family of cytokines, as well as the related cytokine TSLP, in the homeostasis, proliferation and differentiation of various T cell subsets and describe how these cytokines could be exploited for therapeutic purposes.

    • Yrina Rochman
    • Rosanne Spolski
    • Warren J. Leonard
    Reviews
    Nature Reviews Immunology
    Volume: 9, P: 480-490

  • A highly selective JAK3 inhibitor with subnanomolar potency has been used to identify two waves of STAT5 phosphorylation in response to IL-2. This reveals a biphasic role for JAK3 catalytic activity in IL-2-mediated signaling that has therapeutic implications.

    • Warren J Leonard
    • Suman Mitra
    • Jian-Xin Lin
    News & Views
    Nature Chemical Biology
    Volume: 12, P: 308-310

  • The cytokine interleukin-21 (IL-21) regulates immune responses and has potential therapeutic relevance in diseases including cancer, viral infections, autoimmune diseases and allergies. Spolski and Leonard describe our current understanding of IL-21 biology, and discuss progress in harnessing this knowledge therapeutically, including clinical trials of IL-21 itself and molecules that block IL-21 signalling.

    • Rosanne Spolski
    • Warren J. Leonard
    Reviews
    Nature Reviews Drug Discovery
    Volume: 13, P: 379-395