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Showing 1–7 of 7 results
Advanced filters: Author: "Weiping Zou" Clear advanced filters

  • Regulatory T cells have a role in suppressing immune responses against tumours. Here, Weiping Zou reviews the nature of these cells, how they affect current therapeutic protocols and the ways in which their effects can be modified to improve antitumour immunity.

    • Weiping Zou
    Reviews
    Nature Reviews Immunology
    Volume: 6, P: 295-307

  • This Review details how chemokines shape immune responses in the tumour microenvironment through their effects on immune cells, stromal cells and the tumour cells themselves. The authors discuss the potential of targeting chemokine networks for cancer therapy.

    • Nisha Nagarsheth
    • Max S. Wicha
    • Weiping Zou
    Reviews
    Nature Reviews Immunology
    Volume: 17, P: 559-572

  • Histone deacetylase inhibitors, which are in clinical use as anticancer agents, also affect the biology of regulatory T cells. These inhibitors may also hold promise as immunomodulatory drugs (pages 1299–1307).

    • Pavan Reddy
    • Weiping Zou
    News & Views
    Nature Medicine
    Volume: 13, P: 1282-1284

  • There is currently much interest in dissecting the mechanisms of tumor immunity. A new study shows that a subset of CD4+ T cells that produce the cytokine interleukin-9 (IL-9) mediate inhibition of melanoma growth in mice and that analogous IL-9–producing T cells are present in human skin (pages 1248–1253). Could such cells be manipulated to develop new therapeutic strategies for melanoma?

    • Weiping Zou
    • Nicholas P Restifo
    News & Views
    Nature Medicine
    Volume: 18, P: 1177-1178

  • A lot of recent research has focused on T helper 17 (TH17) cells, but their function in the tumour microenvironment has remained controversial. This Review examines the roles of TH17 cells in tumour immunity and discusses the potential of targeting this subset for cancer therapy.

    • Weiping Zou
    • Nicholas P. Restifo
    Reviews
    Nature Reviews Immunology
    Volume: 10, P: 248-256

  • This Review describes how the expression of inhibitory members of the B7 family, particularly B7-H1 and B7-H4, by cancer cells, stromal cells and haematopoietic cells in the tumour microenvironment is regulated and acts to inhibit T-cell immunity, as well as the therapeutic implications.

    • Weiping Zou
    • Lieping Chen
    Reviews
    Nature Reviews Immunology
    Volume: 8, P: 467-477