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Showing 1–4 of 4 results
Advanced filters: Author: "William C. Hahn" Clear advanced filters

  • Cancer-genome sequencing is producing vast amounts of information on genetic alterations in tumours, but how can researchers uncover those changes that influence tumorigenesis? This Review describes how large-scale functional-genomics approaches using an increasing range of sophisticated tools offer a way forward.

    • Jesse S. Boehm
    • William C. Hahn
    Reviews
    Nature Reviews Genetics
    Volume: 12, P: 487-498

  • It is time to move beyond tumour sequencing data to identify vulnerabilities in cancers.

    • Jesse S. Boehm
    • Mathew J. Garnett
    • Francisca Vazquez
    Comments & Opinion
    Nature
    Volume: 589, P: 514-516

  • Orienting cancer drug discovery to the patient requires relating the genetic features of tumors to acquired gene and pathway dependencies and identifying small-molecule therapeutics that target them.

    • Stuart L Schreiber
    • Alykhan F Shamji
    • Bruce A Posner
    Comments & Opinion
    Nature Biotechnology
    Volume: 28, P: 904-906