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Showing 1–5 of 5 results
Advanced filters: Author: "William E. Paul" Clear advanced filters

  • Basophils have long been suspected to be potent inducers of T helper type 2 differentiation. Sokol and colleagues now demonstrate that basophils are required for adoption of the T helper type 2 fate in vivo in response to allergens with protease activity.

    • Booki Min
    • William E Paul
    News & Views
    Nature Immunology
    Volume: 9, P: 223-225

  • Immunologist who won Nobel for genetics of T-cell antigen recognition.

    • Ronald N. Germain
    • William E. Paul
    Comments & Opinion
    Nature
    Volume: 477, P: 34

  • T helper 2 (TH2) cells have a central role in protection against helminth infections but are also responsible for the development of asthma and other allergic inflammatory diseases. This Review provides a comprehensive overview of the cellular and molecular mechanisms involved in the initiation and amplification of TH2-type immune responses in vivo.

    • William E. Paul
    • Jinfang Zhu
    Reviews
    Nature Reviews Immunology
    Volume: 10, P: 225-235

  • Forkhead box O (FOXO) transcription factors have many diverse physiological functions and regulate gene-expression programmes that are involved in immunity, metabolism and oncogenesis. This Review discusses how FOXO proteins integrate different environmental signals in order to regulate T cell differentiation and functions in a context-dependent manner.

    • Stephen M. Hedrick
    • Rodrigo Hess Michelini
    • Erica L. Stone
    Reviews
    Nature Reviews Immunology
    Volume: 12, P: 649-661