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Showing 1–2 of 2 results
Advanced filters: Author: "William T. Yewdell" Clear advanced filters

  • Optimal protein synthesis requires bases in transfer RNAs to be modified. A key modification has been shown to involve an unusual two-step mechanism that entails the sequential activities of two enzymes. See Letter p.494

    • William T. Yewdell
    • Jayanta Chaudhuri
    News & Views
    Nature
    Volume: 542, P: 420-421

  • The targeting of immunoglobulin loci by activation-induced cytidine deaminase (AID) is essential for generating a diverse antibody repertoire. However, AID also has off-target activity in B cells that can lead to oncogenic transformation. Here, the authors review recent advances in our understanding of the mechanisms that drive AID promiscuous activity.

    • Rafael Casellas
    • Uttiya Basu
    • Javier M. Di Noia
    Reviews
    Nature Reviews Immunology
    Volume: 16, P: 164-176