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Advanced filters: Author: "Witold Surewicz" Clear advanced filters

  • Prions are infectious proteins that are involved in brain-wasting disorders such as mad cow disease. In yeast, specific sequences of amino acids in prions seem to mediate prion propagation and cross-species transmissibility.

    • Witold K. Surewicz
    News & Views
    Nature
    Volume: 447, P: 541-542

  • Prion 'strains', multiple conformations of the same misfolded protein, have captured great interest because of their role in transmission of mad cow disease to humans. Prion strains have also been observed in yeast, where self-propagating protein folds are responsible for inheritable traits. Recent findings reveal an exciting new insight into the structural basis of this phenomenon.

    • Nathan J Cobb
    • Witold K Surewicz
    News & Views
    Nature Structural & Molecular Biology
    Volume: 14, P: 882-884