Cheng, Haeberle et al. identify NHC–gold complexes as ligands of the aryl hydrocarbon receptor, which triggers TGFβ production for immune suppression. They find that the MC3 compound activates TGFβ signalling while reducing Il-2 expression and CD4+ T-cell activation and suppresses autoimmune phenotypes in a mouse model of IPEX syndrome.
- Xinlai Cheng
- Stefanie Haeberle
- Stefan. Wölfl