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Showing 1–4 of 4 results
Advanced filters: Author: "X Yang" Clear advanced filters

  • Cancer stem cell (CSC) populations are increasingly recognized in most malignancies and are hypothesized to contribute to cancer proliferation, relapse, and metastasis. Thus, the highly conserved stem-cell signal transduction pathways involved in development and tissue homeostasis that are frequently active in CSCs represent prime targets for targeted therapies against this characteristically treatment-resistant and highly tumorigenic cell population. This Review provides a update on the clinical development of therapies targeting Wnt, Notch, and Hedgehog, three prominent stem-cell signalling pathways that are upregulated in CSCs.

    • Naoko Takebe
    • Lucio Miele
    • S. Percy Ivy
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 12, P: 445-464

  • Noninvasivein vivoimaging to monitor the trafficking or homing of hematopoietic progenitor cells to vascular lesions is essential for both basic research and clinical practice. Here Qiu and Yang examine molecular MRI of stem-progenitor cells in atherosclerosis. They discuss advanced techniques for magnetic labeling of stem-progenitor cells, and how this modality could be used to monitor stem-progenitor cells migrating to injured arteries and vascular gene therapy mediated by stem-progenitor cells.

    • Bensheng Qiu
    • Xiaoming Yang
    Reviews
    Nature Clinical Practice Cardiovascular Medicine
    Volume: 5, P: 396-404