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Showing 1–13 of 13 results
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  • A metasurface is used to generate a hybrid grafted perfect vector vortex beam, which can be dynamically controlled with a half waveplate. The beam has spatially variant rates of polarization change due to the involvement of more topological charges.

    • Hammad Ahmed
    • Muhammad Afnan Ansari
    • Xianzhong Chen
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-8

  • The demonstration of visible frequency metasurfaces with broadband optical response is challenging due to plasmonic losses and non-uniform nanofabrication. Here, Wenet al. demonstrate a helicity multiplexed metasurface hologram capable of achieving high efficiency and image quality in the visible and near infrared.

    • Dandan Wen
    • Fuyong Yue
    • Xianzhong Chen
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-7

  • Angiogenesis is one of the fundamental processes during tumor growth and disease progression, and is regulated by numerous molecular pathways, including, but not limited to, VEGF, matrix metalloproteinases (MMPs), endoglin (CD105), integrin αvβ3and E-selectin. All these pathways could serve as targets for molecular imaging, as outlined in this Viewpoint.

    • Andrei Iagaru
    • Xiaoyuan Chen
    • Sanjiv Sam Gambhir
    Reviews
    Nature Clinical Practice Oncology
    Volume: 4, P: 556-557

  • Heralded detection is widely used in quantum information processing, as it allows real-time tuning the properties of a heralded photon by acting on the heralding photon. With polarization-entangled photon pairs, the authors use a geometric phase metasurface to achieve a remote and continuous control of the vortex states of the heralded photon.

    • Hong Liang
    • Hammad Ahmed
    • Jensen Li
    ResearchOpen Access
    Communications Physics
    Volume: 6, P: 1-7

  • Antiangiogenic agents that target the VEGF pathway have become an important part of standard therapy in multiple cancer indications. Although most adverse effects of VEGF inhibitors are modest and manageable, some are associated with serious and life-threatening consequences. This Review examines the toxicity profiles of anti-VEGF monoclonal antibodies and small-molecule inhibitors and considers the potential mechanisms of the adverse effects, risk factors, and the implications for patient management.

    • Helen X. Chen
    • Jessica N. Cleck
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 6, P: 465-477

  • A key issue in anticancer drug development is how best to select and evaluate potential combinations of the rapidly growing number of molecularly targeted drugs. Dancey and Chen consider development strategies for targeted-agent combinations, highlighting challenges for their rational preclinical and clinical evaluation, and discussing possible approaches to overcoming them.

    • Janet E. Dancey
    • Helen X. Chen
    Reviews
    Nature Reviews Drug Discovery
    Volume: 5, P: 649-659

  • Developing optimal combination strategies for molecularly targeted anticancer drugs is substantially more complex than for traditional chemotherapies. Here, Doroshow and colleagues discuss the lessons learned from the evaluation of combinations of molecularly targeted anticancer agents by the US National Cancer Institute (NCI), and highlight several new approaches that the NCI has initiated to improve the effectiveness of such combinations.

    • Shivanni Kummar
    • Helen X. Chen
    • James H. Doroshow
    Reviews
    Nature Reviews Drug Discovery
    Volume: 9, P: 843-856

  • A single metasurface is used to generate multiple 3D knots with predesigned polarization profiles. At a given region, only a single 3D polarization knot can be obtained for a single color. Different 3D polarization knots can be obtained by changing the incident colors (left). The generated polarization structures are unveiled after passing through a linear polarizer (right).

    • Yuttana Intaravanne
    • Ruoxing Wang
    • Xianzhong Chen
    ResearchOpen Access
    Light: Science & Applications
    Volume: 11, P: 1-10