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Showing 1–10 of 10 results
Advanced filters: Author: "Xi He" Clear advanced filters

  • Two studies suggest that the primary cilium, a microtubule-based structure protruding from the surface of most vertebrate cells, has a role in restraining Wnt/β-catenin signalling. These findings have implications for the pathogenesis of a plethora of diseases associated with abnormal cilia; however, the mechanism linking Wnt signalling and cilia remains a mystery.

    • Xi He
    News & Views
    Nature Cell Biology
    Volume: 10, P: 11-13

  • Modern challenges in oncology, in particular the advent of targeted therapies and personalized medicine, highlight the need for developing a consortium of comprehensive cancer centers to run clinical trials in rare, molecularly-defined populations, and implement high-throughput technologies for daily practice.

    • Thomas Tursz
    • Fabrice Andre
    • Jean-Charles Soria
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 8, P: 177-183

  • KRASmutations can be predictive of resistance to anti-EGFR monoclonal-based therapy in patients with colorectal cancer. Only limited studies, however, have assessed the predictive value ofKRAS mutations in response to conventional chemotherapy. In this Review, the authors assess the available literature and propose that KRASmutations have no value in response prediction to conventional chemotherapy in colorectal cancer, non-small-cell cancer and other solid tumors.

    • Yohann Loriot
    • Pierre Mordant
    • Jean-Charles Soria
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 6, P: 528-534

  • The surgical management of primary severe hypospadias remains controversial. In this Review, Castagnetti and El-Ghoneimi discuss the various preoperative, intraoperative and postoperative factors that might influence the outcome of surgery, and assess the possible advantages and drawbacks of such interventions.

    • Marco Castagnetti
    • Alaa El-Ghoneimi
    Reviews
    Nature Reviews Urology
    Volume: 8, P: 198-206

  • DNA repair as a therapeutic target has received considerable attention in the treatment of non-small-cell lung cancer (NSCLC). In this Review, Postel-Vinay et al. discuss how optimizing treatment of NSCLC according to DNA-repair biomarkers, such as ERCC1, BRCA1 or RRM1, may aid clinical decision making and improve the outcome of patients with NSCLC.

    • Sophie Postel-Vinay
    • Elsa Vanhecke
    • Jean-Charles Soria
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 9, P: 144-155

  • The rapid pace of research in cancer biology, and the advent of molecular targeted therapies has made personalized medicine a reality. This knowledge has generated a vast panel of molecular biomarkers. This Review presents the molecular, prognostic and predictive factors for the six solid tumors associated with the highest mortality. The authors discuss the key biomarkers for each disease site according to its associated clinicopathological presentation and specific associated molecular interactions.

    • Charles Ferté
    • Fabrice André
    • Jean-Charles Soria
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 7, P: 367-380

  • Several toxicities are associated with molecular-targeted drugs including gastrointestinal adverse effects. These adverse effects need to be considered carefully because they can lead to the discontinuation of oral treatment and subsequently compromise cancer control. The authors of this Review discuss the incidence and clinical patterns of the gastrointestinal toxic effects induced by these agents and propose some hypotheses for each adverse event.

    • Yohann Loriot
    • Gabriel Perlemuter
    • Jean-Charles Soria
    Reviews
    Nature Clinical Practice Oncology
    Volume: 5, P: 268-278

  • In a recent issue of Nature, Hao et al. report an unexpected link between the secreted stem cell factor/Wnt agonist R-spondin and Wnt receptors through the transmembrane ZNRF3 protein, a RING finger ubiquitin ligase. ZNRF3 acts to turn over Frizzled and LRP6 receptors. R-spondin binds to ZNRF3, in addition to transmembrane LGR4/5 receptors, to antagonize degradation of the Wnt receptors by ZNRF3, thereby resulting in increased Frizzled and LRP6 levels and a greater Wnt response.

    • Bryan T MacDonald
    • Xi He
    Research Highlights
    Cell Research
    Volume: 22, P: 1410-1412