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Showing 1–2 of 2 results
Advanced filters: Author: "Xiao Zhen Zhou" Clear advanced filters

  • This Review discusses PIN1-catalysed prolyl isomerization as a common signalling mechanism to regulate the balance of oncogenes and tumour suppressors. PIN1 inhibitors may be able to restore the balance in cancer cells and cancer stem cells to treat aggressive and drug-resistant tumours.

    • Xiao Zhen Zhou
    • Kun Ping Lu
    Reviews
    Nature Reviews Cancer
    Volume: 16, P: 463-478

  • Phosphorylation is a universal regulatory mechanism that induces changes in protein conformation. However, certain phosphorylated motifs can be further regulated by the prolyl isomerase PIN1, which is of increasing importance in aspects of physiology and disease.

    • Kun Ping Lu
    • Xiao Zhen Zhou
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 8, P: 904-916