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Showing 1–5 of 5 results
Advanced filters: Author: "Xiaobo Wang" Clear advanced filters

  • Previous studies suggested a chemokine receptor governed gradient of Rac1 activity is essential for collective guidance of Drosophila border cells. Here, Zhou et al. report that two distinct Rac1 pools at protrusions and cables, not Rac1 activity gradient, integrate the direction and coordination for collective guidance.

    • Sijia Zhou
    • Peng Li
    • Xiaobo Wang
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-20

  • During development, organs undergo large scale forces driven by the cytoskeleton but the precise molecular regulation of cytoskeletal networks remains unclear. Here, the authors report a Cdc42-dependent supracellular cytoskeletal network integrates local actomyosin contraction at tissue scale and drives global tissue elongation.

    • Anna Popkova
    • Orrin J. Stone
    • Xiaobo Wang
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • Pulsatile actomyosin contractility during tissue morphogenesis has been mainly studied in apical domains but less is known about the contribution of the basal domain. Here the authors show differential influence of cell-matrix and cell-cell adhesions in regulating oscillations and tissue elongation.

    • Xiang Qin
    • Byung Ouk Park
    • Xiaobo Wang
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16

  • The actomyosin cytoskeleton is known to spontaneously oscillate in many systems but the mechanism of this behavior is not clear. Here Qin et al. define a signaling network involving a ROCK-dependent self-activation loop and recruitment of myosin II to the cortex, followed by a local accumulation of myosin phosphatase that shuts off the signal.

    • Xiang Qin
    • Edouard Hannezo
    • Xiaobo Wang
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15