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Showing 1–2 of 2 results
Advanced filters: Author: "Xiaotu Ma" Clear advanced filters

  • Oncogenic gene fusions are frequent in childhood cancers but remain poorly understood and untargeted. Here, the authors identify 272 oncogenic fusions in transcriptomics data from 5190 childhood cancer patients, revealing their possible etiologies, their links with tumor progression and evolution, and their potential as therapeutic targets.

    • Yanling Liu
    • Jonathon Klein
    • Xiaotu Ma
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18

  • Paediatric therapy-related myeloid neoplasms (tMN) have a dismal prognosis and have not been comprehensively profiled. Here the authors characterise the molecular landscape of 84 paediatric tMN patients, and find that, unlike adult tMNs, these do not emerge from pre-existing clones and that MECOM dysregulation is frequent.

    • Jason R. Schwartz
    • Jing Ma
    • Jeffery M. Klco
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11