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Showing 1–10 of 10 results
Advanced filters: Author: "Y Chang" Clear advanced filters

  • Age-related declines in dehydroepiandrosterone sulfate concentration parallel the physical and cognitive changes of aging. This observation suggests that these events are causally related and that replacement therapy might have beneficial effects in the elderly. The authors of this Viewpoint consider the evidence for, and against, such an approach.

    • Alice Y Chang
    • Hans K Ghayee
    • Richard J Auchus
    Reviews
    Nature Clinical Practice Endocrinology & Metabolism
    Volume: 4, P: 442-443

  • Hydrogen contamination in metals during sample preparation for high-resolution microscopy remains a challenge, especially when hydrogen itself is being investigated. Here, the authors show that using cryogenic milling significantly reduces hydrogen pick-up during sample preparation of titanium and titanium alloys.

    • Yanhong Chang
    • Wenjun Lu
    • Baptiste Gault
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • Long non-coding RNAs (lncRNAs) are a class of RNAs with great molecular and regulatory diversity. This Review discusses how, beyond their lack of protein-coding potential, some types of lncRNAs are known to exhibit features that are distinct from mRNAs, including their transcriptional regulation, localization, processing, biological capabilities and degradation. Such properties underlie many of the key cellular functions of lncRNAs.

    • Jeffrey J. Quinn
    • Howard Y. Chang
    Reviews
    Nature Reviews Genetics
    Volume: 17, P: 47-62

  • The ways in which an RNA molecule folds to form structures can be crucial to its function, and so methods for studying RNA structures make an important contribution to understanding transcriptomes. Experimental approaches in this field are being advanced by coupling them to high-throughput sequencing.

    • Yue Wan
    • Michael Kertesz
    • Howard Y. Chang
    Reviews
    Nature Reviews Genetics
    Volume: 12, P: 641-655

  • The repurposing of a bacterial defence system known as CRISPR into a potent activator of gene expression in human cells enables powerful studies of gene function, as exemplified in cancer cells. See Article p.583

    • Seung Woo Cho
    • Howard Y. Chang
    News & Views
    Nature
    Volume: 517, P: 560-562

  • The discovery of long non-coding RNAs that control the liaisons between a transcription factor with a key role in prostate cancer and its target genes sheds light on how RNAs dictate information flow in the cell nucleus. See Letter p.598

    • Adam M. Schmitt
    • Howard Y. Chang
    News & Views
    Nature
    Volume: 500, P: 536-537

  • Polycomb/Trithorax response elements (PRE/TREs) are genetic elements that can stably silence or activate genes. A new study describes how long noncoding RNAs (lncRNAs) transcribed from opposite strands of the Drosophila melanogaster vestigial PRE/TRE throw the switch between these two opposing epigenetic states.

    • Jeffrey J Quinn
    • Howard Y Chang
    News & Views
    Nature Genetics
    Volume: 46, P: 929-931

  • Introducing four genes into mouse skin fibroblasts reprograms these cells into embryonic stem cells. If similar techniques work in human cells, patient-specific stem cells for tissue engineering and cell-based therapies may be closer to reality.

    • Howard Y Chang
    • George Cotsarelis
    News & Views
    Nature Medicine
    Volume: 13, P: 783-784

  • Substantial interest exists in the effects of immunotherapy; however, radiation therapy also has the potential to stimulate an antitumour immune response. In this Perspectives, the authors describe the rationale for combining immunotherapy with stereotactic ablative radiotherapy based on the available clinical data, and provide recommendations for the future testing of approaches using this combination of treatments.

    • Michael B. Bernstein
    • Sunil Krishnan
    • Joe Y. Chang
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 13, P: 516-524

  • In mammalian cells, DNA double-strand breaks (DSBs) are repaired predominantly by the non-homologous end joining (NHEJ) pathway, which includes subpathways that can repair different DNA-end configurations. Furthermore, the repair of some DNA-end configurations can be shunted to the auxiliary pathways of alternative end joining (a-EJ) or single-strand annealing (SSA).

    • Howard H. Y. Chang
    • Nicholas R. Pannunzio
    • Michael R. Lieber
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 18, P: 495-506