The effect of polymer design on the interfacial structure and physical properties of polymer films in water based on a poly(vinyl ether) platform with hydrophilic side-chains was examined to construct bioinert interfaces. Hydrophilic surfaces were prepared by utilizing the preferential segregation of a rubbery component in a diblock copolymer film with a glassy component, crosslinking a hydrophilic polymer, and designing an interfacial modifier with a special architecture. Interfacial structure and physical properties controlled by polymer design play important roles in determining bioinert properties.
