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Showing 1–3 of 3 results
Advanced filters: Author: "Y. Kwon" Clear advanced filters

  • While a variety of well-established methods enable the control of a stereogenic center, a catalytic method for controlling a stereogenic axis in one substrate is typically unavailable for controlling axial chirality in other substrates with a similar structure. Here, the authors report o-amidobiaryl as a flexible platform for chiral phosphoric acid catalyzed atroposelective dynamic kinetic resolution.

    • Ahreum Kim
    • Chanhee Lee
    • Yongseok Kwon
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11

  • Desymmetrization of symmetric biaryls is an efficient but underexplored way to approach axially chiral molecules. Here, the authors report the atroposelective desymmetrization of 2- arylresorcinols via chiral palladium complex-catalyzed allylic alkylation.

    • Sangji Kim
    • Aram Kim
    • Yongseok Kwon
    ResearchOpen Access
    Communications Chemistry
    Volume: 6, P: 1-10

  • With ELISA-based screening, Woo et al. identify a new small molecule, PRG-A01, which can block the misfolding/aggregation of SOD1 or TDP-43 in a human neuroblastoma cell line. Its use in a mouse model of ALS results in improvement of muscle strength, motor neuron viability and mobility, highlighting its therapeutic potential in ALS.

    • Tae-Gyun Woo
    • Min-Ho Yoon
    • Bum-Joon Park
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-12