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Showing 1–5 of 5 results
Advanced filters: Author: "Yann Barrandon" Clear advanced filters
    • François Majo
    • Ariane Rochat
    • Yann Barrandon
    Research
    Nature
    Volume: 463, P: E11
  • Adult stem cells are thought to be fate restricted to lineages distinct to their tissue of origin. Here, the authors demonstrate that Tp63 expressing epithelial stem cells from several disparate tissues can respond to skin morphogenetic signals and contribute to hair follicles, sebaceous glands and/or epidermis.

    • Stéphanie Claudinot
    • Jun-Ichi Sakabe
    • Yann Barrandon
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13
  • A key step in hair-follicle development is the rearrangement of epithelial stem cells. It seems that reduced production of an adhesion protein, through the concerted action of two signalling pathways, is crucial for this process.

    • Yann Barrandon
    News & Views
    Nature
    Volume: 422, P: 272-273
  • The thymus contains thymic epithelial cells (TECs), which form a complex three-dimensional network organized into cortical and medullary compartments. It is shown here that these cells are plastic. Clonogenic TECs can acquire new properties when exposed to the skin microenvironment; under such conditions, they can permanently adopt the fate of hair follicle multipotent stem cells. Hence, microenvironmental cues can be sufficient to re-direct epithelial cell fate.

    • Paola Bonfanti
    • Stéphanie Claudinot
    • Yann Barrandon
    Research
    Nature
    Volume: 466, P: 978-982