Despite the progress that has been made in designing proteins that mimic native proteins structurally, it is difficult to design functional proteins and particularly challenging to design metalloproteins that reproduce both the structure and function of native metalloenzymes. Here, the successful, rational design of a structural and functional model of a metalloprotein — nitric oxide reductase — is achieved.
- Natasha Yeung
- Ying-Wu Lin
- Yi Lu