This study demonstrates a novel mechanism in neutrophil apoptosis. In vitro, 5-Aza-2′-deoxycytidine (Aza) promotes apoptosis by enhancing death-associated protein kinase 1 (DAPK1) expression and activity. In vivo, Aza treatment accelerates inflammatory resolution in lipopolysaccharide-induced acute respiratory distress syndrome by upregulating DAPK1 expression, resulting in apoptosis of neutrophils.
- Shu-Nan Cui
- Lin Chen
- You Shang