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Showing 1–4 of 4 results
Advanced filters: Author: "Youhua Liu" Clear advanced filters

  • Renal fibrosis is the common final outcome of almost all chronic kidney diseases, and can predict prognosis and determine renal insufficiency. This process consists of four overlapping phases: priming, activation, execution and progression. In this Review, Youhua Liu outlines the cellular and molecular mechanisms of renal fibrosis, which could help the development of new therapeutic strategies.

    • Youhua Liu
    Reviews
    Nature Reviews Nephrology
    Volume: 7, P: 684-696

  • Podocytes are susceptible to injury and undergo a series of adaptive, maladaptive or catastrophic responses depending on the severity and duration of the insult. Emerging evidence indicates a central role for Wnt/β-catenin signalling in mediating podocyte dysfunction and the development of proteinuria. Here, Lili Zhou and Youhua Liu describe advances in current understanding of the pathomechanisms of Wnt/β-catenin signalling in mediating podocyte injury and discuss the therapeutic potential of targeting this pathway for the treatment of proteinuric kidney disease.

    • Lili Zhou
    • Youhua Liu
    Reviews
    Nature Reviews Nephrology
    Volume: 11, P: 535-545

  • The year 2015 has seen great progress in the renal fibrosis field, as key studies began to build a consensus on the importance of epithelial-to-mesenchymal transition, cell cycle arrest, and defective metabolism in the pathogenesis of kidney fibrosis. New findings also point to a role of developmental signalling in renal fibrogenesis.

    • Dong Zhou
    • Youhua Liu
    News & Views
    Nature Reviews Nephrology
    Volume: 12, P: 68-70

  • Renal fibrosis and anaemia are hallmarks of progressive chronic kidney disease (CKD). New evidence demonstrates that these conditions are intimately connected, as injury triggers the phenotypic transition of renal erythropoietin-producing cells into fibrogenic myofibroblasts. Strategies to reverse such a transition may hold promise to alleviate both anaemia and fibrosis in CKD.

    • Liangxiang Xiao
    • Youhua Liu
    News & Views
    Nature Reviews Nephrology
    Volume: 9, P: 563-565