Mesenchymal stem cells (MSCs) actively contribute to the formation of the tumour microenvironment by producing various factors that affect tumour growth and response to therapy. Moreover, MSCs can modulate tumour immunity. This Review discusses the various roles of MSCs in cancer and highlights potential strategies to target pro-tumorigenic activities of MSCs or take advantage of the tumour-homing capacity of MSCs for the delivery of drugs.
- Yufang Shi
- Liming Du
- Ying Wang