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Showing 1–12 of 12 results
Advanced filters: Author: "Yun Huang" Clear advanced filters

  • Existing optogenetic methods to induce calcium mobilisation lack selectivity and specificity. Here, the authors design and engineer a single-component light-operated calcium channel to provide optical control over calcium signals and calcium-dependent physiological responses: LOCa.

    • Lian He
    • Liuqing Wang
    • Yubin Zhou
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • A set of LOV2 circular permutants (cpLOV2) have been engineered to expand the existing optogenetic toolbox. cpLOV2 enables the design of both ON- and OFF-switches to control cell signaling, gene expression, cell fate and cancer immunotherapy.

    • Lian He
    • Peng Tan
    • Yubin Zhou
    Research
    Nature Chemical Biology
    Volume: 17, P: 915-923

  • While chimeric antigen receptor (CAR) T cell-based therapy has been approved for clinical use for certain types of blood cancers, it remains difficult to achieve precise spatiotemporal control of the elicited anti-tumour response. Here, the authors propose light-switchable CAR T cells that can be remotely activated by a nano-optogenetic approach, reducing unwanted side effects.

    • Nhung Thi Nguyen
    • Kai Huang
    • Yubin Zhou
    Research
    Nature Nanotechnology
    Volume: 16, P: 1424-1434

  • Tet-mediated DNA demethylation is intimately involved in reguatling embryonic development. Here the authors characterise DNA methylation and hydroxymethylation dynamics during early cardiac development in both human and mice and provide evidence that Tet-mediated DNA demethylation plays a role in regulating chromatin organization during early heart development.

    • Shaohai Fang
    • Jia Li
    • Yun Huang
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-18

  • Optogenetic tools have been used to control cellular behaviours but their use to probe structure-function relations of signalling proteins are underexplored. Here the authors engineer optogenetic modules into STIM1 to dissect molecular details of STIM1-mediated signalling and control various cellular events.

    • Guolin Ma
    • Lian He
    • Yubin Zhou
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • TET and JBP proteins catalyze the oxidation of methylated C bases in the mammalian genome and of the methyl group of T bases in kinetoplastid genomes, respectively. A recent study in Nature Structural & Molecular Biology suggests a new function of 5-methylcytosine oxidation in regulating RNA polymerase II elongation rate that is reminiscent of that of base J in transcription termination in Leishmania.

    • Yun Huang
    • Anjana Rao
    News & Views
    Nature Structural & Molecular Biology
    Volume: 19, P: 1061-1064

  • Newly identified peptide antagonists of the GPCR Methuselah confirm the role of this receptor in aging and should prove useful as tools for investigating the physiological functions of this class of receptor.

    • Deirdre McGarrigle
    • Xin-Yun Huang
    News & Views
    Nature Chemical Biology
    Volume: 3, P: 371-372

  • Converting somatic cells to induced pluripotent stem cells is becoming routine, but how much do we know about the mechanism of reprogramming? This Review discusses the epigenetic and transcriptional changes that occur and experimental strategies to probe this cell-fate switch.

    • Kathrin Plath
    • William E. Lowry
    Reviews
    Nature Reviews Genetics
    Volume: 12, P: 253-265