ProBDNF can have drastic effects on synaptic function that are quite different from those of mature BDNF. It is, however, controversial whether proBDNF is ever released in amounts that are sufficient to affect normal synaptic plasticity. Here, Yang and colleagues have detected the release of proBDNF from hippocampal neurons using newly developed knock-in mice and antibodies.
- Jianmin Yang
- Chia-Jen Siao
- Barbara L Hempstead