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Showing 1–2 of 2 results
Advanced filters: Author: "Zhiwei Wang" Clear advanced filters

  • F-box proteins, which are the substrate-recognition subunits of SKP1–cullin 1–F-box protein (SCF) E3 ubiquitin ligase complexes, have pivotal roles in multiple cellular processes. This Review discusses how dysregulation of F-box protein-mediated proteolysis contributes to tumorigenesis.

    • Zhiwei Wang
    • Pengda Liu
    • Wenyi Wei
    Reviews
    Nature Reviews Cancer
    Volume: 14, P: 233-247

  • Pancreatic cancer is a highly aggressive malignancy, which is partly attributable to drug resistance. This Review summarizes the current knowledge of the biological significance of the epithelial–mesenchymal transition, cancer stem cells and microRNAs in the context of drug resistance in patients with pancreatic cancer and describes how this knowledge could be applied to overcoming chemoresistance in pancreatic cancer.

    • Zhiwei Wang
    • Yiwei Li
    • Fazlul H. Sarkar
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 8, P: 27-33